Clude the smaller sample size and its retrospective nature. The restricted
Conceived and made the experimentsJD, BL, XW, YF, YL, JL, ZW. Performed the experimentsJD, BL, YW, YL. Analyzed the dataJD, LB. Wrote the paperJD, BL. All authors read and authorized the final manuscript. Monetary assistance by the Wu Jieping Health-related Foundation and also the Science and Technology Development Program of Shandong Province (GG). Author particulars Department of Chemotherapy, Qilu Hospital of Shandong University, No. Wenhuaxi road, Ji'nan, Shandong , China. Shandong Cancer Hospital, Shandong Academy of Healthcare Science, Ji'nan, Shandong , China. ReceivedMay AcceptedJulyReferences . Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. International cancer GA and B. Reductions in polyp area and inside the percentage statistics. CA. ;: Kavallaris M, Kuo DY, Burkhart CA, Regl DL, Norris MD, Haber M, et al. Taxolresistant epithelial ovarian tumors are connected with altered expression of certain betatubulin isotypes. J Clin Invest. ;: Chen L, Liang L, Yan X, Liu N, Gong L, Pan S, et al. Survivin status impacts prognosis and chemosensitivity in epithelial ovarian cancer. Int J Gynecol Cancer. ;: Roque DM, Bellone S, Buza N, Romani C, Cocco E, Bignotti E, et al. Class III betatubulin overexpression in ovarian clear cell and serous carcinoma as a maker for poor overall survival after platinumtaxane chemotherapy and sensitivity to patupilone. Am J Obstet Gynecol. ;e Scaffidi P, Bianchi ME. Spatially precise DNA bending is definitely an crucial activity in the sox transcription issue. J Biol Chem. ;: Chen S, Li X, Lu D, Xu Y, Mou W, Wang L, et al. SOX regulates apoptosis via MAPKSurvivin signaling pathway in human lung cancer cells. Carcinogenesis. ;:. . KulkarniDatar K, Orsulic S, Foster R, Rueda BR. Ovarian tumor initiating cell populations persist following paclitaxel and carboplatin chemotherapy therapy in vivo. Cancer Lett. ;:.Clude the tiny sample size and its retrospective nature. The restricted quantity of patients and missing facts of followup in terms of PFS for patients who received nontaxane chemotherapies may possibly impact the significance of our final results. A larger quantity of situations, and mRNA expression of these possible markers, must be investigated to confirm our findings. Overexpression of Class III tubulin, Sox, and nuclear Survivin could possibly predict taxane resistance and poor progressionfree survival in sufferers with SOEC. Future prospective research evaluating these markers in SOEC patients need to be carried out to identify their clinical potential.Du et al. BMC Cancer :Page ofAdditional filesAdditional file Figure S. KaplanMeier evaluation for progressionfree survival (PFS) in SOEC patients treated with nontaxanebased chemotherapy. There have been no significant associations among expression in the three proteins and PFS p . and . for Class III tubulin (A), Sox (B), only nuclear Survivin (C), and only cytoplasmic Survivin (D), respectively. (JPEG kb) Additional file Figure S. KaplanMeier evaluation for overall survival (OS) in SOEC patients. There had been no significant associations amongst expression of your 3 proteins and OS p and . for Class III tubulin (A), Sox (B), only nuclear Survivin (C), and only cytoplasmic Survivin (D), respectively. (JPEG kb) Abbreviations SOECStage III ovarian epithelial cancer; CSCsCancer stem cells; CRComplete response; PRPartial response; SDStable illness; PDProgression of illness; PFSProgressionfree survival; OSOverall survival. Competing interests The authors declare that they have no competing interests. Authors' contributions Collected information of patientsJD, BL. Conceived and created the experimentsJD, BL, XW, YF, YL, JL, ZW. Performed the experimentsJD, BL, YW, YL. Analyzed the dataJD, LB.